2024

• Biasi A, Marino V, Cortivo GD, Dell'Orco D. Supramolecular complexes of GCAP1: implications for inherited retinal dystrophies. Int J Biol Macromol. 2024 Aug 24:135068. doi: 10.1016/j.ijbiomac.2024.135068.

• Bodenbender JP, Marino V, Philipp J, Tropitzsch A, Kernstock C, Stingl K, Kempf M, Haack TB, Zuleger T, Mazzola P, Kohl S, Weisschuh N, Dell'Orco D, Kühlewein L. Comprehensive analysis of two hotspot codons in the TUBB4B gene and associated phenotypes. Sci Rep. 2024 May 8;14(1):10551. doi: 10.1038/s41598-024-61019-0.

• Marino V, Phromkrasae W, Bertacchi M, Cassini P, Chakrabandhu K, Dell'Orco D, Studer M. Disrupted protein interaction dynamics in a genetic neurodevelopmental disorder revealed by structural bioinformatics and genetic code expansion. Protein Sci. 2024 Apr;33(4):e4953. doi: 10.1002/pro.4953. 

• Sanavia T, Turina P, Morante S, Consalvi V, Lesk AM, Bakolitsa C, Dell'Orco D. Editorial: Computational and experimental protein variant interpretation in the era of precision medicine. Front Mol Biosci. 2024 Jan 15;11:1363813. doi: 10.3389/fmolb.2024.1363813. 

2023

• Dal Cortivo G, Marino V, Zamboni D, Dell'Orco D. Impact of calmodulin missense variants associated with congenital arrhythmia on the thermal stability and the degree of unfolding. Hum Genet. 2023 Dec 28. doi: 10.1007/s00439-023-02629-y. 

• Asteriti S, Marino V, Avesani A, Biasi A, Dal Cortivo G, Cangiano L, Dell'Orco D. Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina. Cell Mol Life Sci. 2023 Nov 25;80(12):371. doi: 10.1007/s00018-023-05022-0.

• Kleinfelder K, Lotti V, Eramo A, Amato F, Lo Cicero S, Castelli G, Spadaro F, Farinazzo A, Dell'Orco D, Preato S, Conti J, Rodella L, Tomba F, Cerofolini A, Baldisseri E, Bertini M, Volpi S, Villella VR, Esposito S, Zollo I, Castaldo G, Laudanna C, Sorsher EJ, Hong J, Joshi D, Cutting G, Lucarelli M, Melotti P, Sorio C. In silico analysis and theratyping of an ultra-rare CFTR genotype (W57G/A234D) in primary human rectal and nasal epithelial cells. iScience. 2023 Oct 12;26(11):108180. doi: 10.1016/j.isci.2023.108180. 

• Marino V, Dal Cortivo G, Dell'Orco D. Ionic displacement of Ca2+ by Pb2+ in calmodulin is affected by arrhythmia-associated mutations. Biochim Biophys Acta Mol Cell Res. 2023 Aug;1870(6):119490. doi: 10.1016/j.bbamcr.2023.119490. Epub 2023 May 17. PMID: 37201768.

• Bodenbender JP, Marino V, Bethge L, Stingl K, Haack TB, Biskup S, Kohl S, Kühlewein L, Dell'Orco D, Weisschuh N. Biallelic Variants in TULP1 Are Associated with Heterogeneous Phenotypes of Retinal Dystrophy. Int. J. Mol. Sci. 2023 Jan 31;24(3):2709. doi: 10.3390/ijms24032709.

• Dal Cortivo G, Marino V, Bianconi S, Dell'Orco D. Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors. Front Mol Biosci. 2023 Jan 5;9:1100992. doi: 10.3389/fmolb.2022.1100992. eCollection 2022.

2022

• Dal Cortivo G, Dell'Orco D. Calcium- and Integrin-Binding Protein 2 (CIB2) in Physiology and Disease: Bright and Dark Sides. Int. J. Mol. Sci. (2022), 23, 3552. https://doi.org/10.3390/ijms23073552

• Avesani A, Bielefeld L, Weisschuh N, Marino V, Mazzola P, Stingl K, Haack TB, Koch KW, Dell'Orco D.  Molecular Properties of Human Guanylate Cyclase-Activating Protein 3 (GCAP3) and Its Possible Association with Retinitis Pigmentosa. Int J Mol Sci. (2022) Mar 17;23(6):3240. doi: 10.3390/ijms23063240.

• Dal Cortivo G, Barracchia CG, Marino V, D'Onofrio M, Dell'Orco D. Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias. Cell. Mol. Life Sci. 79, 127 (2022). https://doi.org/10.1007/s00018-022-04165-w

2021

• Longo R, Avesani A, Dalla Mura G, Dell'Orco D, Manfredini S, Panozzo G. Clinical improvement of ocular surface parameters in dry eye patients following treatment with urea/crosslinked-hyaluronate eyedrops correlates with the secretion of MUC-4. Expert Review of Ophthalmology. (2021) DOI: 10.1080/17469899.2021.1999808 

• Tesolin P, Fiorino S, Lenarduzzi S, Rubinato E, Cattaruzzi E, Ammar L, Castro V, Orzan E, Granata C, Dell'Orco D, Morgan A, Girotto G.  Pendred Syndrome, or Not Pendred Syndrome? That Is the Question. Genes (Basel). 2021 Oct 1;12(10):1569. doi: 10.3390/genes12101569.

• Biasi A, Marino V, Dal Cortivo G, Maltese PE, Modarelli AM, Bertelli M, Colombo L, Dell'Orco D. A Novel GUCA1A Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase. Int J Mol Sci. 2021 Oct 6;22(19):10809. doi: 10.3390/ijms221910809.

• Weisschuh N, Marino V, Schäferhoff K, Richter P, Park J, Haack TB, Dell'Orco D. Mutations at a split codon in the GTPase-encoding domain of OPA1 cause dominant optic atrophy through different molecular mechanisms. Hum Mol Genet. 2021 Sep 24:ddab286. doi: 10.1093/hmg/ddab286.

• Dell'Orco D, Koch KW, Rispoli G. Where vision begins. Pflugers Arch. 2021 Jul 10:1-5. doi: 10.1007/s00424-021-02605-3.

• Beelen CJ, Asteriti S, Cangiano L, Koch KW, Dell'Orco D. A hybrid stochastic/deterministic model of single photon response and light adaptation in mouse rods. Comput Struct Biotechnol J. 202,1 Volume 19, 2021, Pages 3720-3734. doi: https://doi.org/10.1016/j.csbj.2021.06.033

• Marino V, Dal Cortivo G, Maltese PE, Placidi G, De Siena E, Falsini B, Bertelli M, Dell'Orco D. Impaired Ca2+ Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells. Int J Mol Sci. 2021 Apr 14;22(8):4030. doi: 10.3390/ijms22084030.

• Avesani A, Marino V, Zanzoni S, Koch KW, Dell'Orco D. Molecular properties of human guanylate cyclase-activating protein 2 (GCAP2) and its retinal dystrophy-associated variant G157R.  J Biol Chem. 2021 Apr 1;100619. doi: 10.1016/j.jbc.2021.100619

• Kellner U, Weisschuh N, Weinitz S, Farmand G, Deutsch S, Kortüm F, Mazzola P, Schäferhoff K, Marino V, Dell'Orco D. Autosomal Dominant Gyrate Atrophy-Like Choroidal Dystrophy Revisited: 45 Years Follow-Up and Association with a Novel C1QTNF5 Missense Variant. Int J Mol Sci. 2021 Feb 19,22(4):2089. doi: 10.3390/ijms22042089.  Int J Mol Sci. 2021 Feb 19;22(4):2089. doi: 10.3390/ijms22042089.

• Dell'Orco D. Simultaneous detection of reciprocal interactions between calmodulin, Ca2+ and molecular targets: a focus on the calmodulin-RyR2 complex. Biochem J. 2021 Feb 12;478(3):487-491. doi: 10.1042/BCJ20200818.

• Marino V, Riva M, Zamboni D, Koch KW, Dell'Orco D. Bringing the Ca2+ sensitivity of myristoylated recoverin into the physiological range. Open Biol. 2021 Jan;11(1):200346. doi: 10.1098/rsob.200346.

2020

• Iarossi G, Marino V, Maltese PE, Colombo L, D'Esposito F, Manara E, Dhuli K, Modarelli AM, Cennamo G, Magli A, Dell'Orco D, Bertelli M.  Expanding the Clinical and Genetic Spectrum of RAB28-Related Cone-Rod Dystrophy: Pathogenicity of Novel Variants in Italian Families. Int J Mol Sci. 2020 Dec 31;22(1):E381. doi: 10.3390/ijms22010381.

• Bonì F, Marino V, Bidoia C, Mastrangelo E, Barbiroli A, Dell'Orco D, Milani M. Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca2+ or Mg2+: Hints to Understand Protein Activity. Biomolecules. 2020 Oct 5;10(10):E1408. doi: 10.3390/biom10101408. 

• Michelini S, Chiurazzi P, Marino V, Dell'Orco D, Manara E, Baglivo M, Fiorentino A, Maltese PE, Pinelli M, Herbst KL, Dautaj A, Bertelli M. Aldo-Keto Reductase 1C1 (AKR1C1) as the First Mutated Gene in a Family with Nonsyndromic Primary Lipedema. Int J Mol Sci. 2020 Aug 29;21(17):E6264. doi: 10.3390/ijms21176264.

• Dal Cortivo G, Marino V, Bonì F, Milani M, Dell'Orco D. Missense mutations affecting Ca2+-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties. Biochim Biophys Acta Mol Cell Res. 2020 Jul 7;1867(10):118794. doi: 10.1016/j.bbamcr.2020.118794. 

• Abbas S, Marino V, Weisschuh N, Kieninger S, Solaki M, Dell'Orco D, Koch KW.  Neuronal Calcium Sensor GCAP1 Encoded by GUCA1A Exhibits Heterogeneous Functional Properties in Two Cases of Retinitis Pigmentosa.  ACS Chem Neurosci. 2020 May 20;11(10):1458-1470. doi: 10.1021/acschemneuro.0c00111.

• Di Stazio M, Morgan A, Brumat M, Bassani S, Dell'Orco D, Marino V, Garagnani P, Giuliani C, Gasparini P, Girotto G. New age-related hearing loss candidate genes in humans: an ongoing challenge.  Gene. 2020 Mar 12:144561. doi: 10.1016/j.gene.2020.144561

• Abbas S, Marino V, Bielefeld L, Koch KW, Dell'Orco D. Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to "Locking" Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition. Int J Mol Sci. 2020 Jan 23;21(3). pii: E752. doi: 10.3390/ijms21030752.

2019

• Dell'Orco D, Dal Cortivo G. Normal GCAPs partly compensate for altered cGMP signaling in retinal dystrophies associated with mutations in GUCA1A. Sci Rep. 2019 Dec 27;9(1):20105. doi: 10.1038/s41598-019-56606-5.

• Dell'Orco D, Koch KW, Kreutz MR, Naranjo JR, Schwaller B. Editorial: Neuronal Calcium Sensors in Health and Disease. Front Mol Neurosci. 2019 Nov 15;12:278. doi: 10.3389/fnmol.2019.00278

• Abbas S, Marino V, Dell'Orco D, Koch KW. Molecular Recognition of Rhodopsin Kinase GRK1 and Recoverin Is Tuned by Switching Intra- and Intermolecular Electrostatic Interactions. Biochemistry. 2019 Oct 29;58(43):4374-4385. doi: 10.1021/acs.biochem.9b00846. Epub 2019 Oct 21.

• Dal Cortivo G, Marino V, Iacobucci C, Vallone R, Arlt C, Rehkamp A, Sinz A, Dell'Orco D. Oligomeric state, hydrodynamic properties and target recognition of human Calcium and Integrin Binding protein 2 (CIB2). Sci Rep. 2019 Oct 21;9(1):15058. doi: 10.1038/s41598-019-51573-3.

• Borsatto A, Marino V, Abrusci G, Lattanzi G, Dell'Orco D. Effects of Membrane and Biological Target on the Structural and Allosteric Properties of Recoverin: A Computational Approach. Int J Mol Sci. 2019 Oct 10;20(20). pii: E5009. doi: 10.3390/ijms20205009.

• Morgan A, Koboldt DC, Barrie ES, Crist ER, García GG, Mezzavilla M, Faletra F, Mosher TM, Wilson RK, Blanchet C, Manickam K, Roux AF, Gasparini P, Dell'Orco D, Girotto G. Mutations in PLS1, encoding fimbrin, cause autosomal dominant non-syndromic hearing loss. Hum Mutat. 2019 Aug 9. doi: 10.1002/humu.23891.

• Aquila M, Dell'Orco D, Fries R, Koch KW, Rispoli G. Incorporating phototransduction proteins in zebrafish green cone with pressure-polished patch pipettes. Biophys Chem. 2019 Oct;253:106230. doi: 10.1016/j.bpc.2019.106230. Epub 2019 Jul 22.

• Marino V, Dell'Orco D. Evolutionary-Conserved Allosteric Properties of Three Neuronal Calcium Sensor Proteins. Front Mol Neurosci.  2019 Mar 7;12:50. doi: 10.3389/fnmol.2019.00050. eCollection 2019.

2018

• Marino V, Dal Cortivo G, Oppici E, Maltese PE, D'Esposito F, Manara E, Ziccardi L, Falsini B, Magli A, Bertelli M, Dell'Orco D. A novel p.(Glu111Val) missense mutation in GUCA1A associated with cone-rod dystrophy leads to impaired calcium sensing and perturbed second messenger homeostasis in photoreceptors. Hum Mol Genet. 2018 Dec 15;27(24):4204-4217. doi: 10.1093/hmg/ddy311.

• Vallone R, Dal Cortivo G, D'Onofrio M, Dell'Orco D. Preferential Binding of Mg2+ Over Ca2+ to CIB2 Triggers an Allosteric Switch Impaired in Usher Syndrome Type 1J. Front Mol Neurosci. 2018 Aug 17;11:274. doi: 10.3389/fnmol.2018.00274. eCollection 2018.

• Dindo M, Oppici E, Dell'Orco D, Montone R, Cellini B. Correlation between the  molecular effects of mutations at the dimer interface of alanine-glyoxylate aminotransferase leading to primary hyperoxaluria type I and the cellular response to vitamin B(6). J Inherit Metab Dis. 2018 Mar;41(2):263-275. doi: 10.1007/s10545-017-0105-8. Mar;41(2):263-275

• Dal Cortivo G, Wagner GE, Cortelletti P, Padmanabha Das KM, Zangger K, Speghini A, Dell'Orco D, Meyer NH. Luminescent and paramagnetic properties of nanoparticles shed light on their interactions with proteins. Sci Rep. 2018 Feb 21;8(1):3420. doi: 10.1038/s41598-018-21571-y. PubMed PMID: 29467422; PubMed Central PMCID: PMC5821874.

2017

•  Marino V, Borsatto A, Vocke F, Koch KW, Dell'Orco D. CaF(2) nanoparticles as surface carriers of GCAP1, a calcium sensor protein involved in retinal dystrophies. Nanoscale. 2017 Aug 17;9(32):11773-11784. doi: 10.1039/c7nr03288a. PubMed PMID: 28785759.

•  Vocke F, Weisschuh N, Marino V, Malfatti S, Jacobson SG, Reiff CM, Dell'Orco D, Koch KW. Dysfunction of cGMP signalling in photoreceptors by a macular dystrophy-related mutation in the calcium sensor GCAP1. Hum Mol Genet. 2017 Jan 1;26(1):133-144. doi: 10.1093/hmg/ddw374. PubMed PMID: 28025326.

2016

•  Butturini E, Gotte G, Dell'Orco D, Chiavegato G, Marino V, Canetti D, Cozzolino F, Monti M, Pucci P, Mariotto S. Intermolecular disulfide bond influences unphosphorylated STAT3 dimerization and function. Biochem J. 2016 Oct  1;473(19):3205-19. doi: 10.1042/BCJ20160294. Epub 2016 Aug 2. PubMed PMID: 27486258.

• Marino V, Dell'Orco D. Allosteric communication pathways routed by Ca(2+)/Mg(2+) exchange in GCAP1 selectively switch target regulation modes. Sci Rep. 2016 Oct 14;6:34277. doi: 10.1038/srep34277. PubMed PMID: 27739433; PubMed Central PMCID: PMC5064319.

• Dell'Orco D, Koch KW. Fingerprints of Calcium-Binding Protein Conformational Dynamics Monitored by Surface Plasmon Resonance. ACS Chem Biol. 2016 Sep 16;11(9):2390-7. doi: 10.1021/acschembio.6b00470. Epub 2016 Jul 14. Review. PubMed PMID: 27380526.

• Astegno A, La Verde V, Marino V, Dell'Orco D, Dominici P. Biochemical and biophysical characterization of a plant calmodulin: Role of the N- and C-lobes in calcium binding, conformational change, and target interaction. Biochim Biophys Acta. 2016 Mar;1864(3):297-307. doi: 10.1016/j.bbapap.2015.12.003. Epub 2015 Dec PubMed PMID: 26708477.

2015

• Marino V, Scholten A, Koch KW, Dell'Orco D. Two retinal dystrophy-associated missense mutations in GUCA1A with distinct molecular properties result in a similar aberrant regulation of the retinal guanylate cyclase. Hum Mol Genet. 2015 Dec 1;24(23):6653-66. doi: 10.1093/hmg/ddv370. Epub 2015 Sep 10. PubMed PMID:26358777.

•  Koch KW, Dell'Orco D. Protein and Signaling Networks in Vertebrate Photoreceptor Cells. Front Mol Neurosci. 2015 Nov 17;8:67. doi: 10.3389/fnmol.2015.00067. eCollection 2015. Review. PubMed PMID: 26635520; PubMed Central PMCID: PMC4646965.

• Robin J, Brauer J, Sulmann S, Marino V, Dell'Orco D, Lienau C, Koch KW. Differential Nanosecond Protein Dynamics in Homologous Calcium Sensors. ACS Chem  Biol. 2015 Oct 16;10(10):2344-52. doi: 10.1021/acschembio.5b00278. Epub 2015 Aug  PubMed PMID: 26204433.

•  Zernii EY, Grigoriev II, Nazipova AA, Scholten A, Kolpakova TV, Zinchenko DV, Kazakov AS, Senin II, Permyakov SE, Dell'Orco D, Philippov PP, Koch KW. Regulatory function of the C-terminal segment of guanylate cyclase-activating protein 2. Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1325-37. doi: 10.1016/j.bbapap.2015.05.005. Epub 2015 May 19. PubMed PMID: 26001899.

•  Marino V, Sulmann S, Koch KW, Dell'Orco D. Structural effects of Mg²⁺ on the  regulatory states of three neuronal calcium sensors operating in vertebrate phototransduction. Biochim Biophys Acta. 2015 Sep;1853(9):2055-65. doi: 10.1016/j.bbamcr.2014.10.026. Epub 2014 Nov 4. PubMed PMID: 25447547.

• Asteriti S, Dal Cortivo G, Pontelli V, Cangiano L, Buffelli M, Dell'Orco D. Effective delivery of recombinant proteins to rod photoreceptors via lipid nanovesicles. Biochem Biophys Res Commun. 2015 Jun 12;461(4):665-70. doi: 10.1016/j.bbrc.2015.04.088. Epub 2015 Apr 25. PubMed PMID: 25918020.

• Dell'Orco D, Koch KW. Transient complexes between dark rhodopsin and transducin: circumstantial evidence or physiological necessity? Biophys J. 2015 Feb 3;108(3):775-7. doi: 10.1016/j.bpj.2014.12.031. PubMed PMID: 25650944; PubMed Central PMCID: PMC4317538.

•  Dell'Orco D. Rhodopsin transient complexes investigated by systems biology approaches. Methods Mol Biol. 2015;1271:251-63. doi: 10.1007/978-1-4939-2330-4_17. PubMed PMID: 25697529.

2014

• Köster M, Dell'Orco D, Koch KW. The interaction network of rhodopsin involving the heterotrimeric G-protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes. FEBS J. 2014 Dec;281(23):5175-85. doi: 10.1111/febs.13064. Epub 2014 Oct 13. PubMed PMID: 25243418.

• Astegno A, Maresi E, Marino V, Dominici P, Pedroni M, Piccinelli F, Dell'Orco D. Structural plasticity of calmodulin on the surface of CaF2 nanoparticles preserves its biological function. Nanoscale. 2014 Dec 21;6(24):15037-47. doi:10.1039/c4nr04368e. Epub 2014 Nov 4. PubMed PMID: 25367003.

•  Dell'Orco D, Sulmann S, Zägel P, Marino V, Koch KW. Impact of cone dystrophy-related mutations in GCAP1 on a kinetic model of phototransduction. Cell Mol Life Sci. 2014 Oct;71(19):3829-40. doi: 10.1007/s00018-014-1593-4. Epub  2014 Feb 25. PubMed PMID: 24566882.

•  Butturini E, Darra E, Chiavegato G, Cellini B, Cozzolino F, Monti M, Pucci P, Dell'Orco D, Mariotto S. S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation. ACS Chem Biol. 2014 Aug 15;9(8):1885-93. doi: 10.1021/cb500407d. Epub 2014 Jun 27. PubMed PMID: 24941337.

•  Invergo BM, Dell'Orco D, Montanucci L, Koch KW, Bertranpetit J. A comprehensive model of the phototransduction cascade in mouse rod cells. Mol Biosyst. 2014 Jun;10(6):1481-9. doi: 10.1039/c3mb70584f. Epub 2014 Mar 28. PubMed PMID: 24675755.

• Sulmann S, Dell'Orco D, Marino V, Behnen P, Koch KW. Conformational changes in calcium-sensor proteins under molecular crowding conditions. Chemistry. 2014 May 26;20(22):6756-62. doi: 10.1002/chem.201402146. Epub 2014 Mar 27. PubMed PMID: 24677478.

•  Dell'Orco D, Lundqvist M, Linse S, Cedervall T. Mathematical modeling of the  protein corona: implications for nanoparticulate delivery systems. Nanomedicine (Lond). 2014 May;9(6):851-8. doi: 10.2217/nnm.14.39. PubMed PMID: 24981650.

•  Marino V, Astegno A, Pedroni M, Piccinelli F, Dell'Orco D. Nanodevice-induced conformational and functional changes in a prototypical calcium sensor protein. Nanoscale. 2014 Jan 7;6(1):412-23. doi: 10.1039/c3nr04978g. Epub 2013 Nov 8.PubMed PMID: 24213152.

2013

• Aquila M, Benedusi M, Dell'Orco D. Biophysical characterization of antimicrobial peptides activity: from in vitro to ex vivo techniques. Curr Protein Pept Sci. 2013 Nov;14(7):607-16. Review. PubMed PMID: 24106959.

•  Zägel P, Dell'Orco D, Koch KW. The dimerization domain in outer segment guanylate cyclase is a Ca²⁺-sensitive control switch module. Biochemistry. 2013 Jul 30;52(30):5065-74. doi: 10.1021/bi400288p. Epub 2013 Jul 17. PubMed PMID:23815670.

• Dell'Orco D. A physiological role for the supramolecular organization of rhodopsin and transducin in rod photoreceptors. FEBS Lett. 2013 Jun 27;587(13):2060-6. doi: 10.1016/j.febslet.2013.05.017. Epub 2013 May 16. Review. PubMed PMID: 23684654.

•  Koch KW, Dell'orco D. A calcium-relay mechanism in vertebrate phototransduction. ACS Chem Neurosci. 2013 Jun 19;4(6):909-17. doi: 10.1021/cn400027z. Epub 2013 Mar 21. Review. PubMed PMID: 23472635; PubMed Central PMCID: PMC3689192.

• Invergo BM, Montanucci L, Koch KW, Bertranpetit J, Dell'orco D. Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling. Cell Commun Signal. 2013 May 21;11(1):36. doi: 10.1186/1478-811X-11-36. PubMed PMID: 23693153; PubMed Central PMCID: PMC3732082.

• Aquila M, Benedusi M, Koch KW, Dell'Orco D, Rispoli G. Divalent cations modulate membrane binding and pore formation of a potent antibiotic peptide analog of alamethicin. Cell Calcium. 2013 Mar;53(3):180-6. doi: 10.1016/j.ceca.2012.11.012. Epub 2012 Dec 20. PubMed PMID: 23261317.

• Cangiano L, Dell'Orco D. Detecting single photons: a supramolecular matter? FEBS Lett. 2013 Jan 4;587(1):1-4. doi: 10.1016/j.febslet.2012.11.015. Epub 2012 Nov 23. Review. PubMed PMID: 23178927.

•  Mariani S, Dell'Orco D, Felline A, Raimondi F, Fanelli F. Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases. PLoS Comput Biol. 2013;9(8):e1003207. doi: 10.1371/journal.pcbi.1003207. Epub 2013 Aug 29. PubMed PMID: 24009494; PubMed Central PMCID: PMC3757061.

2012

• Dell'Orco D, Lundqvist M, Cedervall T, Linse S. Delivery success rate of engineered nanoparticles in the presence of the protein corona: a systems-level screening. Nanomedicine. 2012 Nov;8(8):1271-81. doi: 10.1016/j.nano.2012.02.006.  Epub 2012 Feb 24. PubMed PMID: 22366597.

•  Dell'Orco D, Sulmann S, Linse S, Koch KW. Dynamics of conformational Ca2+-switches in signaling networks detected by a planar plasmonic device. Anal Chem. 2012 Mar 20;84(6):2982-9. doi: 10.1021/ac300213j. Epub 2012 Mar 8. PubMed PMID: 22404528.

Prior to 2012

•  Dell'Orco D, Koch KW. A dynamic scaffolding mechanism for rhodopsin and transducin interaction in vertebrate vision. Biochem J. 2011 Dec 1;440(2):263-71. doi: 10.1042/BJ20110871. PubMed PMID: 21843151.

• Zernii EY, Komolov KE, Permyakov SE, Kolpakova T, Dell'orco D, Poetzsch A, Knyazeva EL, Grigoriev II, Permyakov EA, Senin II, Philippov PP, Koch KW. Involvement of the recoverin C-terminal segment in recognition of the target enzyme rhodopsin kinase. Biochem J. 2011 Apr 15;435(2):441-50. doi: 10.1042/BJ20110013. PubMed PMID: 21299498.

•  Dell'Orco D, Müller M, Koch KW. Quantitative detection of conformational transitions in a calcium sensor protein by surface plasmon resonance. Chem Commun (Camb). 2010 Oct 21;46(39):7316-8. doi: 10.1039/c0cc02086a. Epub 2010 Sep 10.PubMed PMID: 20835460.

•  Dell'Orco D, Koch KW. Systems biochemistry approaches to vertebrate phototransduction: towards a molecular understanding of disease. Biochem Soc Trans. 2010 Oct;38(5):1275-80. doi: 10.1042/BST0381275. PubMed PMID: 20863298.

• Dell'Orco D, Lundqvist M, Oslakovic C, Cedervall T, Linse S. Modeling the time evolution of the nanoparticle-protein corona in a body fluid. PLoS One. 2010 Jun 3;5(6):e10949. doi: 10.1371/journal.pone.0010949. PubMed PMID: 20532175; PubMed Central PMCID: PMC2880601.

• Behnen P, Dell'Orco D, Koch KW. Involvement of the calcium sensor GCAP1 in hereditary cone dystrophies. Biol Chem. 2010 Jun;391(6):631-7. doi:10.1515/BC.2010.063. Review. PubMed PMID: 20370318.

• Dell'Orco D, Behnen P, Linse S, Koch KW. Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy. Cell Mol Life Sci. 2010 Mar;67(6):973-84. doi:10.1007/s00018-009-0243-8. PubMed PMID: 20213926.

•  Dell'Orco D, Schmidt H, Mariani S, Fanelli F. Network-level analysis of light adaptation in rod cells under normal and altered conditions. Mol Biosyst. 2009 Oct;5(10):1232-46. doi: 10.1039/b908123b. Epub 2009 Jul 7. PubMed PMID: 19756313.

• Dell'Orco D. Fast predictions of thermodynamics and kinetics of protein-protein recognition from structures: from molecular design to systems biology. Mol Biosyst. 2009 Apr;5(4):323-34. doi: 10.1039/b821580d. Epub 2009 Feb 19. Review. PubMed PMID: 19396368. 

• Casciari D, Dell'Orco D, Fanelli F. Homodimerization of neurotensin 1 receptor involves helices 1, 2, and 4: insights from quaternary structure predictions and dimerization free energy estimations. J Chem Inf Model. 2008 Aug;48(8):1669-78. doi: 10.1021/ci800048d. Epub 2008 Jul 16. PubMed PMID:18627138.

•  Dell'Orco D, Casciari D, Fanelli F. Quaternary structure predictions and estimation of mutational effects on the free energy of dimerization of the OMPLA  protein. J Struct Biol. 2008 Aug;163(2):155-62. doi: 10.1016/j.jsb.2008.05.006. Epub 2008 May 23. PubMed PMID: 18599313.

• Dell'Orco D, De Benedetti PG. Quantitative structure-activity relationship analysis of canonical inhibitors of serine proteases. J Comput Aided Mol Des. 2008 Jun-Jul;22(6-7):469-78. doi: 10.1007/s10822-008-9175-x. Epub 2008 Jan 23. PubMed PMID: 18217217.

• Dell'Orco D, Schmidt H. Mesoscopic Monte Carlo simulations of stochastic encounters between photoactivated rhodopsin and transducin in disc membranes. J Phys Chem B. 2008 Apr 10;112(14):4419-26. doi: 10.1021/jp709963f. Epub 2008 Mar 18. PubMed PMID: 18345658.

• Fanelli F, Dell'orco D. Dark and photoactivated rhodopsin share common binding modes to transducin. FEBS Lett. 2008 Mar 19;582(6):991-6. doi: 10.1016/j.febslet.2008.02.041. Epub 2008 Feb 26. PubMed PMID: 18307992.

•  Dell'Orco D, De Benedetti PG, Fanelli F. In silico screening of mutational effects on transmembrane helix dimerization: insights from rigid-body docking and molecular dynamics simulations. J Phys Chem B. 2007 Aug 2;111(30):9114-24. Epub 2007 Jun 28. PubMed PMID: 17602582.

•  Dell'Orco D, De Benedetti PG, Fanelli F. In silico screening of mutational effects on enzyme-proteic inhibitor affinity: a docking-based approach. BMC Struct Biol. 2007 Jun 8;7:37. PubMed PMID: 17559675; PubMed Central PMCID: PMC1913526.

•  Dell'Orco D, Seeber M, Fanelli F. Monomeric dark rhodopsin holds the molecular determinants for transducin recognition: insights from computational analysis. FEBS Lett. 2007 Mar 6;581(5):944-8. Epub 2007 Feb 6. PubMed PMID: 17300784.

• Fanelli F, Dell'Orco D. Rhodopsin activation follows precoupling with transducin: inferences from computational analysis. Biochemistry. 2005 Nov 15;44(45):14695-700. PubMed PMID: 16274216.

• Dell'Orco D, Seeber M, De Benedetti PG, Fanelli F. Probing fragment complementation by rigid-body docking: in silico reconstitution of calbindin D9k. J Chem Inf Model. 2005 Sep-Oct;45(5):1429-38. PubMed PMID: 16180920.

• Dell'Orco D, Xue WF, Thulin E, Linse S. Electrostatic contributions to the kinetics and thermodynamics of protein assembly. Biophys J. 2005 Mar;88(3):1991-2002. Epub 2004 Dec 13. PubMed PMID: 15596501; PubMed Central PMCID: PMC1305251.